By Gustavo Maroni
Drosophila, the typical fruit fly, is the main widely studied of all organisms from the perspective of genetics and cytology. This atlas summarizes what's identified in regards to the nearly a hundred Drosophila genes for which the whole nucleotide series is understood. every one access encompasses a description of the gene's molecular association and expression, the total nucleotide and amino acid sequences, maps of attention-grabbing constructions, highlights of sensible positive aspects and promoter regulatory areas, and chosen references to the first literature. A separate element of the atlas considers varied facets of gene association as they ensue within the Drosophila genome. themes coated comprise dimension correlations between a number of genetic components, splicing signs, translation initiation signs, and codon bias. The paintings represents a brand new milestone in summarizing present info and making it simply obtainable to geneticists and biologists.
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Additional resources for An Atlas of Drosophila Genes: Sequences and Molecular Features
H. and Hickey, D. A. (1986). The a-amylase gene in Drosophila melanogaster: nucleotide sequence, gene structure and expression motifs. Nucl. Acids Res. 14:8399-8411. Doane, W. , Kolar, M. , Martenson, R. E. and Deibler, G. E. (1975). Purified Drosophila alpha-amylase isozymes: genetical, biochemical and molecular characterization. In Isozymes: Current Topics in Biological and Medical Research, ed. L. Markert (New York, NY: Alan R. Liss), Volume 4, 585-607. Doane, W. , Treat-Clemons, L. , Gemmill, R.
1989). Alternative 5C actin transcripts are localized in different patterns during Drosophila embryogenesis. Dev. Biol. 131:345-355. -T. and Keller, E. B. (1990a). Regulatory elements mediating transcription from the Drosophila melanogaster Actin 5C proximal promoter. Mol. Cell. Biol. 10:206-216. -T. and Keller, E. B. (1990b). Positive and negative regulatory elements mediating transcription from the Drosophila melanogaster Actin 5C distal promoter. Mol. Cell. Biol. 10:6172-6180. Couderc, J. , Sobrier, M.
1989, 1991). Adult Enhancer and Distal Promoter The adult enhancer is located between 600 and 450 bp upstream of the distal transcription initiation site (approximately —1,375 and —1,225 in the Adh Sequence); it stimulates transcription from both promoters but only during the late third larval instar and in adults (Corbin and Maniatis 1989a). DNA-binding assays and in vitro transcription experiments defined a cis-acting region that extends from — 860 to — 820 as necessary for transcription from the distal promoter; a specific factor, ADF-1 (Adh distal factor 1), binds to this region (dx in the Adh Sequence) (Heberlein et al.