Download Aging Phenomena: Relationships among Different Levels of by A. Macieira-Coelho (auth.), Kunio Oota, Masami Iriki, PDF

By A. Macieira-Coelho (auth.), Kunio Oota, Masami Iriki, Takashi Makinodan, Lynn S. Baker (eds.)

The challenge of senescence, as mirrored within the historical past of reli­ gion and philosophy, has lengthy been one of many maximum issues of humankind. against this, gerontology as a department of technological know-how continues to be relatively younger. prior to now decade, concomitant with quick development in our realizing of the fundamental existence sciences, great shops of information approximately organic getting older were accrued. this data, in spite of the fact that, bobbing up from many medical disciplines and fascinated with various degrees of biologic association, turns out nearly random and covers every thing from molecules to human societies. Theories complex to interpret the proof and to appreciate the mech­ anisms thinking about senescence have remained in person, instead of basic, territories. It has lengthy been felt by way of a few gerontologists that it was once time for many of the experts to step again and take a generalist view of gerontology, to reassess and reevaluate the culmination in their analyt­ ical ambitions at diverse degrees inside of a broader context. a few others might imagine it nonetheless untimely. It appeared, even though, that most of these who amassed in Tokyo at the celebration of the XIth foreign Congress of Gerontology have been of the opinion that there has been a lot to be received in searching for interrelationships one of the evidence and theories originated within the diverse degrees of investiga­ tion in an try to become aware of and take pleasure in the organic drama of senescence as an entity.

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Hallen, Mode of degradation of the chondroitin sulfate proteoglycan in rat costal cartilage, Biochem. J. 130:729 (1972). J. D. Salvo and M. Schubert, Specific interaction of some cartilage protein-polysaccharides with freshly precipitating calcium phosphate, J. Biol. Chem. 242:705 (1967). R. D. Campo, C. D. Tourtellotte, and R. J. Bielen, The proteinpolysaccharides of articular, epiphyseal plate and costal cartilages, Biochim. Biophys. Acta 177:501 (1969). HYDRODYNAMIC PROPERTIES OF COLLAGEN FIBRIL AND AGING Toshiharu Matsumura Department of Cancer Cell Research Institute of Medical Science University of Tokyo Shirokanedai, Minato-ku, Tokyo 108 Japan INTRODUCTION One biochemical approach to aging research has been to isolate bodily structural components, study their physiochemical properties, and establish the molecular basis for bodily changes during the aging process.

VI, Aging," W. , Pergamon Press, Oxford (1964). W. G. Banfield, Width and length of collagen fibrils during the development of human skin, in granulation tissue and in the skin of adult animals, J. Gerontol. 10:13 (1955). W. SChwarz, Morphology and-differentiation of the connective tissue fibres, in: "Connective Tissue," R. E. Tunbridge, M. Keech, J. F. Delafresnaye, and G. C. , Blackwell Scientific Publications, Oxford (1957). J. W. Smith, Molecular pattern in native collagen, Natur~ 219:157 (1968).

Nq loneoqe Fig. 3. A hypothetical scheme for the proliferation and multinucleation of cultured human liver cells. The cells at the bottom are the descendants of a single cell, shown at the top. Clonogenic cells are represented by cells with filled nuclei. Nonclonogenic cells are represented by cells with open nuclei. l£le and "Cell Spiral" Mode!.. Experimental studies using pulse labelling and cinemicrography will tell much about the mode of multinucleation and polyploidization in culture. While these studies are in progress, this author would like to interpret the results summarized above by presenting a hypothetical model.

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